Trusted Prescription Drug Information

• Tramadol may increase the risk of seizures especially in patients who have epilepsy or another seizure disorder. Also, tramadol may increase the risk of seizures if you are taking any of the following drugs:
· a tricyclic antidepressant such as amitriptyline (Elavil), nortriptyline (Pamelor), doxepin (Sinequan), imipramine (Tofranil), clomipramine (Anafranil), and others;
· a monoamine oxidase inhibitor (MAOI) such as isocarboxazid (Marplan), phenelzine (Nardil), or tranylcypromine (Parnate);
· an antipsychotic medication such as chlorpromazine (Thorazine), fluphenazine (Prolixin), haloperidol (Haldol), loxapine (Loxitane), mesoridazine (Serentil), perphenazine (Trilafon), thioridazine (Mellaril), thiothixene (Navane), and others;
· a selective serotonin reuptake inhibitor (SSRI) such as fluoxetine (Prozac), fluvoxamine (Luvox), paroxetine (Paxil), sertraline (Zoloft), or citalopram (Celexa);
· a narcotic pain reliever such as codeine, fentanyl (Duragesic), hydromorphone (Dilaudid), meperidine (Demerol), hydrocodone (Vicodin, Lorcet, Lortab, others), morphine (MS Contin, MSIR, RMS, Roxanol, others), oxycodone (Roxicodone, Percocet, Percodan, others), propoxyphene (Darvon, Darvocet, others), and others;
· promethazine (Phenergan) or prochlorperazine (Compazine);
· bupropion (Wellbutrin, Zyban); or
· cyclobenzaprine (Flexeril).
• Do not take tramadol without first talking to your doctor if you are taking any of the medicines listed above.
• Before taking tramadol, tell your doctor if you are taking any of the following medicines:
· carbamazepine (Tegretol);
· quinidine (Quinaglute Dura-Tabs, Cardioquin, Quinora, others);
· warfarin (Coumadin); or
· digoxin (Lanoxin, Lanoxicaps).
• You may not be able to take tramadol, or you may require a dosage adjustment or special monitoring during treatment if you are taking any of the medicines listed above.
• Tramadol may increase the effects of other drugs that cause drowsiness, including antidepressants, alcohol, antihistamines, sedatives (used to treat insomnia), other pain relievers, anxiety medicines, and muscle relaxants. Tell your doctor about all medicines that you are taking, and do not take any other prescription or over-the-counter medicines, including herbal products, without first talking to your doctor during treatment with tramadol.
• Drugs other than those listed here may also interact with tramadol. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines, including herbal products.